Article

Enhanced Anti-Liver Tumor Efficacy of Chimeric Antigen Receptor-T Cells via SATB1 Modulation

2025-06-18

Abstract excerpt

<title>Abstract</title> <p> Although Chimeric antigen receptor (CAR) T-cell therapy has achieved remarkable success in treating hematopoietic malignancies, its clinical application in solid tumors is profoundly hindered by persistent T-cell exhaustion within the immunosuppressive tumor microenvironment (TME). Here, we identified SATB1—a genome organizer regulating chromatin architecture—as a key suppressor of CA...

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Literature Corpus work: 7b59b80b-ebe2-5bdf-a995-eda9f2317ea3
DOI: 10.21203/rs.3.rs-6776099/v1

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