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Article

Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals.

PLoS computational biology - 1 Nov 2021

Hoskins Jason W, Chung Charles C, O'Brien Aidan, Zhong Jun, Connelly Katelyn, Collins Irene, Shi Jianxin, Amundadottir Laufey T

Abstract excerpt

Expression QTL (eQTL) analyses have suggested many genes mediating genome-wide association study (GWAS) signals but most GWAS signals still lack compelling explanatory genes. We have leveraged an adipose-specific gene regulatory network to infer expression regulator activities and phenotypic master regulators (MRs), which were used to detect activity QTLs (aQTLs) at cardiometabolic trait GWAS loci. Regulator...

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Identifiers

PMID: 34793442
DOI: 10.1371/journal.pcbi.1009563
PMCID: PMC8639061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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