Article

Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

2021-09-30

Abstract excerpt

<h4>Background</h4> Identification of causal genes for polygenic human diseases has been extremely challenging, and our understanding of how physiological and pharmacological stimuli modulate genetic risk at disease-associated loci is limited. Specifically, insulin resistance (IR), a common feature of cardiometabolic disease, including type 2 diabetes, obesity, and dyslipidemia, lacks well-powered GWAS, and theref...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f60081c-3678-5c78-ab6f-427d9dd83262
DOI: 10.1101/2021.09.28.21264208

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genesDOI 10.1101/2021.09.28.21264208Read

Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits.Semantic proximity Read

Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits.Semantic proximity Read

Insights Into Causal Effects of Genetically Proxied Lipids and Lipid-Modifying Drug Targets on Cardiometabolic Diseases.Semantic proximity Read

Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease MechanismsSemantic proximity Read

Systematic Integration of genomics with transcriptomics for the Study of Coronary Artery Disease and Subclinical AtherosclerosisSemantic proximity Read

An integrated approach to identify environmental modulators of genetic risk factors for complex traits.Semantic proximity Read

An integrated approach to identify environmental modulators of genetic risk factors for complex traitsSemantic proximity Read

Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin ResistanceSemantic proximity Read

Multi-omics uncovers the pleiotropic genetic mechanisms linking MASLD and cardiometabolic syndromes.Semantic proximity Read

Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging.Semantic proximity Read

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease.Semantic proximity Read

A multi-trait genome-wide association study of coronary artery disease and subclinical atherosclerosis traitsSemantic proximity Read