Article

Transcripts with high distal heritability mediate genetic effects on complex metabolic traits

2024-09-27

Abstract excerpt

Although many genes are subject to local regulation, recent evidence suggests that complex distal regulation may be more important in mediating phenotypic variability. To assess the role of distal gene regulation in complex traits, we combined multi-tissue transcriptomes with physiological outcomes to model diet-induced obesity and metabolic disease in a population of Diversity Outbred mice. Using a novel high-dim...

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Literature Corpus work: 8d9028f2-4d5a-5a81-8c02-7dda61a738a0
DOI: 10.1101/2024.09.26.613931

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