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Article

Master regulator activity QTL protocol to implicate regulatory pathways potentially mediating GWAS signals using eQTL data.

STAR protocols - 15 Sept 2023

Hoskins Jason W, Christensen Trevor A, Amundadottir Laufey T

Abstract excerpt

Here, we present a protocol to identify transcriptional regulators potentially mediating downstream biological effects of germline variants associated with complex traits of interest, which enables functional hypothesis generation independent of colocalizing expression quantitative trait loci (eQTLs). We describe steps for tissue-/cell-type-specific co-expression network modeling, expression regulator activity...

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Identifiers

PMID: 37330907
DOI: 10.1016/j.xpro.2023.102362
PMCID: PMC10285694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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