Article

Probabilistic fine-mapping of transcriptome-wide association studies

2017-12-20

Abstract excerpt

Transcriptome-wide association studies (TWAS) using predicted expression have identified thousands of genes whose locally-regulated expression is associated to complex traits and diseases. In this work, we show that linkage disequilibrium (LD) among SNPs induce significant gene-trait associations at non-causal genes as a function of the overlap between eQTL weights used in expression prediction. We introduce a pro...

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Literature Corpus work: d9b18b08-f6a7-5d0e-94ff-36c9b0e31b6f
DOI: 10.1101/236869

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