Genetics of gene expression and its effect on disease.

doi:10.1038/nature06758

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Article

Genetics of gene expression and its effect on disease.

Nature - 27 Mar 2008

Emilsson Valur, Thorleifsson Gudmar, Zhang Bin, Leonardson Amy S, Zink Florian, Zhu Jun, Carlson Sonia, Helgason Agnar, Walters G Bragi, Gunnarsdottir Steinunn, Mouy Magali, Steinthorsdottir Valgerdur, Eiriksdottir Gudrun H, Bjornsdottir Gyda, Reynisdottir Inga, Gudbjartsson Daniel, Helgadottir Anna, Jonasdottir Aslaug, Jonasdottir Adalbjorg, Styrkarsdottir Unnur, Gretarsdottir Solveig, Magnusson Kristinn P, Stefansson Hreinn, Fossdal Ragnheidur, Kristjansson Kristleifur, Gislason Hjortur G, Stefansson Tryggvi, Leifsson Bjorn G, Thorsteinsdottir Unnur, Lamb John R, Gulcher Jeffrey R, Reitman Marc L, Kong Augustine, Schadt Eric E, Stefansson Kari

Abstract excerpt

Common human diseases result from the interplay of many genes and environmental factors. Therefore, a more integrative biology approach is needed to unravel the complexity and causes of such diseases. To elucidate the complexity of common human diseases such as obesity, we have analysed the expression of 23,720 transcripts in large population-based blood and adipose tissue cohorts comprehensively assessed for...

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PMID: 18344981
DOI: 10.1038/nature06758

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