Article
Integrative functional genomics and fine-mapping identify regulatory mechanisms of multivariate obesity GWAS and its cardiometabolic implications.
Metabolism: clinical and experimental - 1 Apr 2026
Wang Suijian, Liu Sihua, Zhang Hongqiang, Sun Lijie, Tan Huiling, Shi Yu, Pan Lanxin, Geng Mengya, Chen Minghui, Gao Beibei, Wang Kui, Zhang Haoqiang, Yue Tong, Weng Jianping, Zheng Xueying
Abstract excerpt
BACKGROUND: Obesity is a systemic disorder with heterogeneous fat distribution and complex metabolic complications. Conventional genome-wide association studies (GWAS) typically analyze individual obesity-related traits separately, limiting the identification of shared genetic architecture and key regulatory mechanisms, particularly those involving non-coding variants. METHODS: We integrated GWAS data for five...
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