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Article

Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables.

PLoS genetics - 1 Nov 2024

Khan Mariyam, Ludl Adriaan-Alexander, Bankier Sean, Björkegren Johan L M, Michoel Tom

Abstract excerpt

Multivariate Mendelian randomization (MVMR) is a statistical technique that uses sets of genetic instruments to estimate the direct causal effects of multiple exposures on an outcome of interest. At genomic loci with pleiotropic gene regulatory effects, that is, loci where the same genetic variants are associated to multiple nearby genes, MVMR can potentially be used to predict candidate causal genes. However,...

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PMID: 39527631
DOI: 10.1371/journal.pgen.1011473
PMCID: PMC11581411

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