Article
Integrative approaches for large-scale transcriptome-wide association studies.
Nature genetics - 1 Mar 2016
Gusev Alexander, Ko Arthur, Shi Huwenbo, Bhatia Gaurav, Chung Wonil, Penninx Brenda W J H, Jansen Rick, de Geus Eco J C, Boomsma Dorret I, Wright Fred A, Sullivan Patrick F, Nikkola Elina, Alvarez Marcus, Civelek Mete, Lusis Aldons J, Lehtimäki Terho, Raitoharju Emma, Kähönen Mika, Seppälä Ilkka, Raitakari Olli T, Kuusisto Johanna, Laakso Markku, Price Alkes L, Pajukanta Päivi, Pasaniuc Bogdan
Abstract excerpt
Many genetic variants influence complex traits by modulating gene expression, thus altering the abundance of one or multiple proteins. Here we introduce a powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide association studies (GWAS) to identify genes whose cis-regulated expression is associated with complex traits. We leverage expression...
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