Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

doi:10.1126/science.aad6970

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Article

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

Science (New York, N.Y.) - 19 Aug 2016

Franzén Oscar, Ermel Raili, Cohain Ariella, Akers Nicholas K, Di Narzo Antonio, Talukdar Husain A, Foroughi-Asl Hassan, Giambartolomei Claudia, Fullard John F, Sukhavasi Katyayani, Köks Sulev, Gan Li-Ming, Giannarelli Chiara, Kovacic Jason C, Betsholtz Christer, Losic Bojan, Michoel Tom, Hao Ke, Roussos Panos, Skogsberg Josefin, Ruusalepp Arno, Schadt Eric E, Björkegren Johan L M

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of cardiometabolic disease (CMD) risk loci. However, they contribute little to genetic variance, and most downstream gene-regulatory mechanisms are unknown. We genotyped and RNA-sequenced vascular and metabolic tissues from 600 coronary artery disease patients in the Stockholm-Tartu Atherosclerosis Reverse Networks Engineering Task study (STARNET)....

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PMID: 27540175
DOI: 10.1126/science.aad6970
PMCID: PMC5534139

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PCSK9

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