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The role of R-spondin proteins in cancer biology

18 Oct 2021

Abstract excerpt

R-spondin (RSPO) proteins constitute a family of four secreted glycoproteins (RSPO1-4) that have appeared as multipotent signaling ligands. The best-known molecular function of RSPOs lie within their capacity to agonize the Wnt/β-catenin signaling pathway. As RSPOs act upon cognate receptors LGR4/5/6 that are typically expressed by stem cells and progenitor cells, RSPO proteins importantly potentiate...

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PMID: 34663878
DOI: 10.1038/s41388-021-02059-y

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