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Article

R‐spondin‐3 is an oncogenic driver of poorly differentiated invasive breast cancer

9 Aug 2022

Abstract excerpt

R-spondins (RSPOs) are influential signaling molecules that promote the Wnt/β-catenin pathway and self-renewal of stem cells. Currently, RSPOs are emerging as clinically relevant oncogenes, being linked to cancer development in multiple organs. Although this has instigated the rapid development and testing of therapeutic antibodies targeting RSPOs, functional evidence that RSPO causally drives cancer has focused...

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PMID: 36106661
DOI: 10.1002/path.5999

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