Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer.

doi:10.1158/1078-0432.CCR-21-3018

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Article

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 2 May 2022

Seeber Andreas, Battaglin Francesca, Zimmer Kai, Kocher Florian, Baca Yasmine, Xiu Joanne, Spizzo Gilbert, Novotny-Diermayr Veronica, Rieder Dietmar, Puccini Alberto, Swensen Jeff, Ellis Michelle, Goldberg Richard M, Grothey Axel, Shields Anthony F, Marshall John L, Weinberg Benjamin A, Sackstein Paul E, Lim Kiat Hon, Tan Gek San, Nabhan Chadi, Korn W Michael, Amann Arno, Trajanoski Zlatko, Berger Martin D, Lou Emil, Wolf Dominik, Lenz Heinz-Josef

Abstract excerpt

PURPOSE: Gene fusions involving R-spondin (RSPOfp) and RNF43 mutations have been shown to drive Wnt-dependent tumor initiation in colorectal cancer. Herein, we aimed to characterize the molecular features of RSPOfp/RNF43 mutated (mut) compared with wild-type (WT) colorectal cancers to gain insights into potential rationales for therapeutic strategies. EXPERIMENTAL DESIGN: A discovery cohort was classified for...

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PMID: 35254413
DOI: 10.1158/1078-0432.CCR-21-3018
PMCID: PMC9064897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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