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RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunities

19 Apr 2023

Abstract excerpt

R-spondins are secretory proteins localized in the endoplasmic reticulum and Golgi bodies and are processed through the secretory pathway. Among the R-spondin family, RSPO2 has emanated as a novel regulator of Wnt signaling, which has now been acknowledged in numerous in vitro and in vivo studies. Cancer is an abnormal growth of cells that proliferates and spreads uncontrollably due to the accumulation of genetic...

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PMID: 37692504
DOI: 10.1016/j.gendis.2023.01.013

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