Article

Palmdelphin facilitates R-spondin2 secretion to activate Wnt signaling and promote colorectal cancer stemness and tumorigenesis

2025-04-10

Abstract excerpt

The Wnt signaling pathway is a key driver of stemness and progression which contributes to mortality in colorectal cancer (CRC). R-spondins bind to LGR receptors to inhibit ubiquitin E3 ligases, thus protecting Frizzled from degradation and activating downstream Wnt signaling. Herein, we identify Palmdelphin ( PALMD ) as a functional marker of CRC stem cells, interspersed between intestinal and colonic crypt base...

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Literature Corpus work: 3f06ef54-0383-5549-b603-7f95952bf8ee
DOI: 10.1101/2025.04.03.646911

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