Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

R-Spondin Proteins: A Novel Link to &beta;-catenin Activation

5 Dec 2005

Abstract excerpt

The R-spondin (Rspo) protein family is a recently described group of four distinct human secreted proteins. Reported activities for Rspo proteins include essential roles in vertebrate development and their ligand-type activities overlap substantially with those of the canonical Wnt ligands in that both Rspo and canonical Wnt signaling result in the activation of beta-catenin. In a general functional screen for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heat shock proteins research
Share to Peptidase Inhibition and Analysis
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16357527
DOI: 10.4161/cc.5.1.2305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

R-Spondin Proteins: A Novel Link to &beta;-catenin ActivationPMID 16357527Read ↗

The R-spondin family of proteins: emerging regulators of WNT signaling.Semantic proximity Read ↗

The role of R-spondin proteins in cancer biologySemantic proximity Read ↗

R-spondin family biology and emerging linkages to cancerSemantic proximity Read ↗

A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signalingSemantic proximity Read ↗

Mitogenic Influence of Human R-Spondin1 on the Intestinal EpitheliumSemantic proximity Read ↗

RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunitiesSemantic proximity Read ↗

R‐spondin‐mediated WNT signaling potentiation in mammary and breast cancer developmentSemantic proximity Read ↗

The R-spondin protein family.Semantic proximity Read ↗

R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast CancersSemantic proximity Read ↗

Structural basis for R-spondin recognition by LGR4/5/6 receptors.Semantic proximity Read ↗

Clinical value of R-spondins in triple-negative and metaplastic breast cancersSemantic proximity Read ↗

Human RSPO1/R-spondin1 Is Expressed during Early Ovary Development and Augments β-Catenin SignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.