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R‐spondin‐mediated WNT signaling potentiation in mammary and breast cancer development

31 Mar 2020

Abstract excerpt

The mammary gland is a secretory organ, which develops as a network of growing epithelial ducts composed of luminal and basal cells that invade the surrounding adipose tissue through a series of developmental cycles. Mammary stem cells (MaSCs) maintain an accurate tissue homeostasis, and their proliferation and cell fate determination are regulated by multiple hormones and local factors. The WNT pathway plays a...

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PMID: 32233118
DOI: 10.1002/iub.2278

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