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R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers

15 Dec 2020

Abstract excerpt

Wnt signaling is activated in many cancer types, yet targeting the canonical Wnt pathway has been challenging for cancer therapy. The pathway might be effectively targeted at many levels depending on the mechanism by which it has become hyperactive. Recently, mouse genetic screens have found that R-spondins (RSPOs) act as oncogenes. Evidence includes recurrent genomic rearrangements that led to increased RSPO2 or...

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PMID: 33320737
DOI: 10.1089/dna.2020.5585

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