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R‐spondin 2 Drives Liver Tumor Development in a Yes‐Associated Protein‐Dependent Manner

3 Sept 2019

Abstract excerpt

Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in development and promote tissue stem cell renewal. In cancer, RSPOs 2 and 3 are oncogenes first identified by insertional mutagenesis screens in tumors induced by mouse mammary...

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PMID: 31701073
DOI: 10.1002/hep4.1422

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