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R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

11 Jul 2017

Abstract excerpt

Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted therapies. Chromosome rearrangements are a common feature of human malignancies, but whether they represent bona fide cancer drivers and therapeutically actionable targets, requires functional testing. Here, we describe the generation of transgenic, inducible CRISPR-based mouse systems to...

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PMID: 28695896
DOI: 10.1038/ncomms15945

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