Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

R-spondin family biology and emerging linkages to cancer

16 Jan 2023

Abstract excerpt

The R-spondin protein family comprises four members (RSPO1-4), which are agonists of the canonical Wnt/β-catenin pathway. Emerging evidence revealed that RSPOs should not only be viewed as agonists of the Wnt/β-catenin pathway but also as regulators for tumor development and progression. Aberrant expression of RSPOs is related to tumorigenesis and tumor development in multiple cancers and their expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cancer-related Molecular Pathways
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36645115
DOI: 10.1080/07853890.2023.2166981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

R-spondin family biology and emerging linkages to cancerPMID 36645115Read ↗

The role of R-spondin proteins in cancer biologySemantic proximity Read ↗

The R-spondin family of proteins: emerging regulators of WNT signaling.Semantic proximity Read ↗

RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunitiesSemantic proximity Read ↗

R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast CancersSemantic proximity Read ↗

R‐spondin‐mediated WNT signaling potentiation in mammary and breast cancer developmentSemantic proximity Read ↗

Clinical value of R-spondins in triple-negative and metaplastic breast cancersSemantic proximity Read ↗

R-Spondin Proteins: A Novel Link to &beta;-catenin ActivationSemantic proximity Read ↗

Expression and Prognostic Values of the Roof Plate-Specific Spondin Family in Bladder Cancer.Semantic proximity Read ↗

R‐spondin‐3 is an oncogenic driver of poorly differentiated invasive breast cancerSemantic proximity Read ↗

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer.Semantic proximity Read ↗

Structural basis for R-spondin recognition by LGR4/5/6 receptors.Semantic proximity Read ↗

Palmdelphin facilitates R-spondin2 secretion to activate Wnt signaling and promote colorectal cancer stemness and tumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.