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Article

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.

Gut - 1 Jun 2017

Hilkens John, Timmer Nikki C, Boer Mandy, Ikink Gerjon J, Schewe Matthias, Sacchetti Andrea, Koppens Martijn A J, Song Ji-Ying, Bakker Elvira R M

Abstract excerpt

OBJECTIVE: The gross majority of colorectal cancer cases results from aberrant Wnt/β-catenin signalling through adenomatous polyposis coli (APC) or CTNNB1 mutations. However, a subset of human colon tumours harbour, mutually exclusive with APC and CTNNB1 mutations, gene fusions in RSPO2 or RSPO3, leading to enhanced expression of these R-spondin genes. This suggested that RSPO activation can substitute for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27511199
DOI: 10.1136/gutjnl-2016-311606
PMCID: PMC5532462

Genes

RSPO3
APC
CTNNB1
RSPO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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