Article

Cellular energy regulates mRNA translation and degradation in a codon-specific manner

2023-04-06

Abstract excerpt

<h4>Background:</h4> Codon optimality is a major determinant of mRNA translation and degradation rates. However, whether and through which mechanisms its effects are regulated remains poorly understood. <h4>Results</h4> Here we show that codon optimality associates with up to 2-fold change in mRNA stability variations between human tissues, and that its effect is attenuated in tissues with high energy metabolism...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ef3c1e74-597e-5558-9579-b94be321c940
DOI: 10.1101/2023.04.06.535836

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cellular energy regulates mRNA translation and degradation in a codon-specific mannerDOI 10.1101/2023.04.06.535836Read

Codon optimality in cancer.Semantic proximity Read

Synonymous codon usage regulates translation initiationSemantic proximity Read

Codon usage and amino acid identity are major determinants of mRNA stability in humansSemantic proximity Read

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decaySemantic proximity Read

Translational efficiency across healthy and tumor tissues is proliferation-relatedSemantic proximity Read

Using protein-per-mRNA differences among human tissues in codon optimizationSemantic proximity Read

Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesSemantic proximity Read

The translational machinery is an optimized molecular network that affects cellular homoeostasis and disease.Semantic proximity Read

Codon bias coevolves with longevitySemantic proximity Read

Analysis at single-cell resolution identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neuronsSemantic proximity Read

Variation of Human Transfer RNA Demand and SupplySemantic proximity Read

Position-dependent Codon Usage Bias in the Human TranscriptomeSemantic proximity Read