Article
Codon Bias as a Means to Fine-Tune Gene Expression.
Molecular cell - 16 Jul 2015
Quax Tessa E F, Claassens Nico J, Söll Dieter, van der Oost John
Abstract excerpt
The redundancy of the genetic code implies that most amino acids are encoded by multiple synonymous codons. In all domains of life, a biased frequency of synonymous codons is observed at the genome level, in functionally related genes (e.g., in operons), and within single genes. Other codon bias variants include biased codon pairs and codon co-occurrence. Although translation initiation is the key step in protein...
Topics
- Animals
- Cell Cycle
- Cell Differentiation
- Codon
- Gene Expression
- Genes, Synthetic
- Genetic Code
- Genetic Variation
- Humans
- Operon
- Protein Biosynthesis
- Protein Folding
- RNA, Transfer
- Selection, Genetic