Article

Using protein-per-mRNA differences among human tissues in codon optimization

2022-03-22

Abstract excerpt

Codon usage and nucleotide composition of coding sequences have profound effects on protein expression. However, while it is recognized that different tissues have distinct tRNA profiles and codon usages in their transcriptomes, the effect of tissue-specific codon optimality on protein synthesis remains elusive. Here, we leverage existing state-of-the-art transcriptomics and proteomics datasets from the GTEx proje...

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Literature Corpus work: 3aa71064-8936-5ec2-bf60-587380f8af5a
DOI: 10.1101/2022.03.22.485268

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