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Article

A basal-level activity of ATR links replication fork surveillance and stress response.

Molecular cell - 21 Oct 2021

Yin Yandong, Lee Wei Ting Chelsea, Gupta Dipika, Xue Huijun, Tonzi Peter, Borowiec James A, Huang Tony T, Modesti Mauro, Rothenberg Eli

Abstract excerpt

Mammalian cells use diverse pathways to prevent deleterious consequences during DNA replication, yet the mechanism by which cells survey individual replisomes to detect spontaneous replication impediments at the basal level, and their accumulation during replication stress, remain undefined. Here, we used single-molecule localization microscopy coupled with high-order-correlation image-mining algorithms to...

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Identifiers

PMID: 34473946
DOI: 10.1016/j.molcel.2021.08.009
PMCID: PMC8541912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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