Article

Replication-induced DNA secondary structures drive fork uncoupling and breakage

2022-11-18

Abstract excerpt

Sequences that can form DNA secondary structures, such as G-quadruplexes (G4s) and intercalated-Motifs (iMs), are abundant in the human genome and play a range of physiological roles. However, they can also pose a challenge to the replication machinery and in turn threaten genome stability. Multiple lines of evidence suggest G4s interfere with replication, but the underlying mechanism remains unclear. Moreover, th...

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Literature Corpus work: 22eda79c-f9b3-5ef3-bbde-de46fb28a2e9
DOI: 10.1101/2022.11.18.517070

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