Article

Replisome loading reduces chromatin motion independent of DNA synthesis

2023-03-07

Abstract excerpt

<h4>SUMMARY</h4> Chromatin has been shown to undergo diffusional motion, which is affected during gene transcription by RNA polymerase activity. However, the relationship between chromatin mobility and other genomic processes remains unclear. Hence, we set out to label the DNA directly in a sequence unbiased manner and followed labeled chromatin dynamics in interphase human cells expressing GFP-tagged PCNA, a cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31592f58-1e2f-5f74-a42d-4c987d0ba120
DOI: 10.1101/2023.03.07.531331

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Replisome loading reduces chromatin motion independent of DNA synthesisDOI 10.1101/2023.03.07.531331Read

Direct visualization of MCM helicase activation and replisome coupling in situSemantic proximity Read

Cell Cycle-Dependent Chromatin Motion: A Role for DNA Content Doubling Over CohesionSemantic proximity Read

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cellsSemantic proximity Read

Repli-seq: genome-wide analysis of replication timing by next-generation sequencingSemantic proximity Read

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read

Sequencing newly replicated DNA reveals widespread plasticity in human replication timingSemantic proximity Read

Replication-dependent histone (Repli-Histo) labeling dissects the physical properties of euchromatin/heterochromatin in living human cellsSemantic proximity Read

Genome-wide identification of replication fork stalling/pausing sites and the interplay between RNA Pol II transcription and DNA replication progressionSemantic proximity Read

Acceleration of genome replication uncovered by single-cell nascent DNA sequencingSemantic proximity Read

Optimized Repli-seq: Improved DNA Replication Timing Analysis by Next-Generation SequencingSemantic proximity Read

SMARCAD1 Regulates R-Loops at Active Replication Forks Linked to Cancer Mutation HotspotsSemantic proximity Read

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing controlSemantic proximity Read