Article

RF-SIRF defining reversed DNA replication forks with single-cell and spatio-temporal resolution reveals a replication stress specific epigenetic code

2025-04-22

Abstract excerpt

DNA replication stress responses are key genomic stability guardians critical during development, aging, hematopoiesis, disease suppression and cancer therapy response. Reversed forks (RF) form at stalled DNA replication forks as a distinct four-way DNA structure to protect against formation and exposure to toxic DNA lesions. So far, prevailing methods to measure RFs involve specialized electron microscopy preclud...

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Literature Corpus work: b855efa2-1d33-58d9-a785-710f3fbf7470
DOI: 10.1101/2025.04.21.649830

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