Article

ATR and TopBP1 oppose to control dormant origin building, providing a first defence against replication stress

2024-10-07

Abstract excerpt

<title>Abstract</title> <p>Replication stress, a major hallmark of cancers, sources from replication fork slowing or blocking. In response, activation of extra-origins, otherwise dormant, supports the replication rate. Whether the DNA replication checkpoint drives this compensation process remained unclear. Here, DNA combing analyses show that a linear relationship ties inter-origin distances to fork speeds and t...

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Literature Corpus work: 75e5580c-1ff3-5ae0-8afc-5817e98597c1
DOI: 10.21203/rs.3.rs-5124760/v1

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