Article

Spatial mapping of DNA synthesis reveals dynamics and geometry of human replication nanostructures

2025-02-23

Abstract excerpt

DNA replication is essential to life and ensures the accurate transmission of genetic information, which is significantly disturbed during cancer development and chemotherapy. While DNA replication is tightly controlled in time and space, methods to visualise and quantify replication dynamics within 3D human cells are lacking. Here, we introduce 3D-Spatial Assay for Replication Kinetics (3D-SPARK), an approach ena...

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Literature Corpus work: 82c45c84-4cc1-5481-bac2-dfb0013fa71f
DOI: 10.1101/2025.02.21.639251

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