Article

Cumulative microscopy reveals cellular states in fibroblasts from patients with genetic disorders

2025-08-06

Abstract excerpt

Analysis of cellular states and signaling trajectories can provide insights into causes of disease. We developed cumulative microscopy, a method to perform cyclical imaging without elution or quenching steps. Cumulative microscopy computationally extracts individual signals from accumulating fluorescence during sequential imaging. We used cumulative microscopy to quantitatively assess cell cycle and stress markers...

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Literature Corpus work: e9190d3c-62f2-5b5d-9308-68a5ad50beeb
DOI: 10.1101/2025.08.04.668398

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