Article

Actin nucleation safeguards single-stranded DNA and promotes replication fork protection

2021-09-02

Abstract excerpt

<title>Abstract</title> <p>Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to replicative stress and protect stalled replication forks. All such responses rely on the formation of Replication Protein A (RPA)-ssDNA complexes, yet supra-physiological binding of RPA to ssDNA is toxic. How cells regulate RPA availability t...

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Literature Corpus work: 41ba2ed7-294a-5a51-9ee0-76a26c5cc775
DOI: 10.21203/rs.3.rs-806457/v1

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