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A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

19 Aug 2025

Abstract excerpt

DNA replication stress is a hallmark of cancer that is exploited by chemotherapies. Current assays for replication stress have low throughput and poor resolution whilst being unable to map the movement of replication forks genome-wide. We present a new method that uses nanopore sequencing and artificial intelligence to map forks and measure their rates of movement and stalling in melanoma and colon cancer cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40830365
DOI: 10.1038/s41467-025-63168-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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