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Article

Revisiting the consequences of deleting the X inactivation center.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2021

Yin Hao, Wei Chunyao, Lee Jeannie T

Abstract excerpt

Mammalian cells equalize X-linked dosages between the male (XY) and female (XX) sexes by silencing one X chromosome in the female sex. This process, known as "X chromosome inactivation" (XCI), requires a master switch within the X inactivation center (Xic). The Xic spans several hundred kilobases in the mouse and includes a number of regulatory noncoding genes that produce functional transcripts. Over three...

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Identifiers

PMID: 34161282
DOI: 10.1073/pnas.2102683118
PMCID: PMC8237661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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