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Article

Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic.

Science (New York, N.Y.) - 7 Dec 2007

Augui S, Filion G J, Huart S, Nora E, Guggiari M, Maresca M, Stewart A F, Heard E

Abstract excerpt

Mammalian dosage compensation involves silencing of one of the two X chromosomes in females and is controlled by the X-inactivation center (Xic). The Xic, which includes Xist and its antisense transcription unit Tsix/Xite, somehow senses the number of X chromosomes and triggers Xist up-regulation...

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Source

Identifiers

PMID: 18063799
DOI: 10.1126/science.1149420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18063799-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic.PMID 18063799Read ↗

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Chromosomal silencing and localization are mediated by different domains of Xist RNA.Semantic proximity Read ↗

Regulation of X-chromosome inactivation by the X-inactivation centre.Semantic proximity Read ↗

Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolutionSemantic proximity Read ↗

Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expressionSemantic proximity Read ↗

A long noncoding RNA influences the choice of the X chromosome to be inactivated.Semantic proximity Read ↗

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