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Article

Xite, X-inactivation intergenic transcription elements that regulate the probability of choice.

Molecular cell - 1 Mar 2003

Ogawa Yuya, Lee Jeannie T

Abstract excerpt

Allelic expression differences contribute to phenotypic variation. In X chromosome inactivation (XCI), unfavorable XCI ratios promote X-linked disease penetrance in females. During XCI, one X is randomly silenced by Xist. X chromosome choice is determined by asymmetric expression of Tsix whose antisense action represses Xist. Here, we discover a cis element in the mouse X-inactivation center that regulates Tsix....

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Identifiers

PMID: 12667455
DOI: 10.1016/s1097-2765(03)00063-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Xite, X-inactivation intergenic transcription elements that regulate the probability of choice.PMID 12667455Read ↗

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A long noncoding RNA influences the choice of the X chromosome to be inactivated.Semantic proximity Read ↗

Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation.Semantic proximity Read ↗

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Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic.Semantic proximity Read ↗

Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolutionSemantic proximity Read ↗

A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice.Semantic proximity Read ↗

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