Xite, X-inactivation intergenic transcription elements that regulate the probability of choice.

doi:10.1016/s1097-2765(03)00063-7

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Article

Xite, X-inactivation intergenic transcription elements that regulate the probability of choice.

Molecular cell - 1 Mar 2003

Ogawa Yuya, Lee Jeannie T

Abstract excerpt

Allelic expression differences contribute to phenotypic variation. In X chromosome inactivation (XCI), unfavorable XCI ratios promote X-linked disease penetrance in females. During XCI, one X is randomly silenced by Xist. X chromosome choice is determined by asymmetric expression of Tsix whose antisense action represses Xist. Here, we discover a cis element in the mouse X-inactivation center that regulates Tsix....

Topics

Alleles
Animals
Bacterial Outer Membrane Proteins
Base Sequence
CpG Islands
Deoxyribonuclease I
Down-Regulation
Escherichia coli Proteins
Exons
Female
Gene Deletion
Gene Expression Regulation
Genes, Regulator
In Situ Hybridization, Fluorescence
Male

Source

Open in PubMed

Identifiers

PMID: 12667455
DOI: 10.1016/s1097-2765(03)00063-7

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Mice

Mice, Knockout

Models, Genetic