Article
The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 2021
Liu Yang, Wang Lu, Xu Xin, Yuan Yue, Zhang Bo, Li Zeyang, Xie Yuchen, Yan Rui, Zheng Zeqi, Ji Jianguo, Murray Johanne M, Carr Antony M, Kong Daochun
Abstract excerpt
DNA replication is dramatically slowed down under replication stress. The regulation of replication speed is a conserved response in eukaryotes and, in fission yeast, requires the checkpoint kinases Rad3ATR and Cds1Chk2 However, the underlying mechanism of this checkpoint regulation remains unresolved. Here, we report that the Rad3ATR-Cds1Chk2 checkpoint directly targets the Cdc45-MCM-GINS (CMG) replicative...
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