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Article

ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.

Genes & development - 15 Dec 2002

Shimada Kenji, Pasero Philippe, Gasser Susan M

Abstract excerpt

The intra-S-phase checkpoint in yeast responds to stalled replication forks by activating the ATM-like kinase Mec1 and the CHK2-related kinase Rad53, which in turn inhibit spindle elongation and late origin firing and lead to a stabilization of DNA polymerases at arrested forks. A mutation that destabilizes the second subunit of the Origin Recognition Complex, orc2-1, reduces the number of functional replication...

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Identifiers

PMID: 12502744
DOI: 10.1101/gad.239802
PMCID: PMC187497

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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