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Article

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.

Molecular cell - 2 Sept 2005

Szyjka Shawn J, Viggiani Christopher J, Aparicio Oscar M

Abstract excerpt

Mrc1 associates with replication forks, where it transmits replication stress signals and is required for normal replisome pausing in response to nucleotide depletion. Mrc1 also plays a poorly understood role in DNA replication, which appears distinct from its role in checkpoint signaling. Here, we demonstrate that Mrc1 functions constitutively to promote normal replication fork progression. In mrc1Delta cells,...

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Source

Identifiers

PMID: 16137624
DOI: 10.1016/j.molcel.2005.06.037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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