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Article

Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.

Molecular biology of the cell - 1 Oct 2008

Yin Ling, Locovei Alexandra Monica, D'Urso Gennaro

Abstract excerpt

In the fission yeast, Schizosaccharomyces pombe, blocks to DNA replication elongation trigger the intra-S phase checkpoint that leads to the activation of the Cds1 kinase. Cds1 is required to both prevent premature entry into mitosis and to stabilize paused replication forks. Interestingly, although Cds1 is essential to maintain the viability of mutants defective in DNA replication elongation, mutants defective...

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Identifiers

PMID: 18667534
DOI: 10.1091/mbc.e08-01-0020
PMCID: PMC2555949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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