Article
Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction.
International journal of molecular sciences - 13 Dec 2020
Denkiewicz-Kruk Milena, Jedrychowska Malgorzata, Endo Shizuko, Araki Hiroyuki, Jonczyk Piotr, Dmowski Michal, Fijalkowska Iwona J
Abstract excerpt
The CMG complex (Cdc45, Mcm2-7, GINS (Psf1, 2, 3, and Sld5)) is crucial for both DNA replication initiation and fork progression. The CMG helicase interaction with the leading strand DNA polymerase epsilon (Pol ε) is essential for the preferential loading of Pol ε onto the leading strand, the stimulation of the polymerase, and the modulation of helicase activity. Here, we analyze the consequences of impaired...
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