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Article

Fork pausing complex engages topoisomerases at the replisome.

Genes & development - 1 Jan 2020

Shyian Maksym, Albert Benjamin, Zupan Andreja Moset, Ivanitsa Vitalii, Charbonnet Gabriel, Dilg Daniel, Shore David

Abstract excerpt

Replication forks temporarily or terminally pause at hundreds of hard-to-replicate regions around the genome. A conserved pair of budding yeast replisome components Tof1-Csm3 (fission yeast Swi1-Swi3 and human TIMELESS-TIPIN) act as a "molecular brake" and promote fork slowdown at proteinaceous replication fork barriers (RFBs), while the accessory helicase Rrm3 assists the replisome in removing protein obstacles....

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Source

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Identifiers

PMID: 31805522
DOI: 10.1101/gad.331868.119
PMCID: PMC6938670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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