Critical Function of γH2A in S-Phase.

doi:10.1371/journal.pgen.1005517

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Critical Function of γH2A in S-Phase.

PLoS genetics - 1 Sept 2015

Mejia-Ramirez Eva, Limbo Oliver, Langerak Petra, Russell Paul

Abstract excerpt

Phosphorylation of histone H2AX by ATM and ATR establishes a chromatin recruitment platform for DNA damage response proteins. Phospho-H2AX (γH2AX) has been most intensively studied in the context of DNA double-strand breaks caused by exogenous clastogens, but recent studies suggest that DNA replication stress also triggers formation of γH2A (ortholog of γH2AX) in Schizosaccharomyces pombe. Here, a focused genetic...

Topics

DNA Polymerase II
DNA, Fungal
Histones
Mutation
Proliferating Cell Nuclear Antigen
Protein Binding
S Phase
Schizosaccharomyces
Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26368543
DOI: 10.1371/journal.pgen.1005517
PMCID: PMC4569340

Genes

PCNA
ATR
ATM

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.