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Article

Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing.

Oncogene - 12 Feb 2004

Lucca Chiara, Vanoli Fabio, Cotta-Ramusino Cecilia, Pellicioli Achille, Liberi Giordano, Haber James, Foiani Marco

Abstract excerpt

The replication checkpoint controls the integrity of replicating chromosomes by stabilizing stalled forks, thus preventing the accumulation of abnormal replication and recombination intermediates that contribute to genome instability. Checkpoint-defective cells are susceptible to rearrangements at chromosome fragile sites when replication pauses, and certain human cancer prone diseases suffer checkpoint...

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Identifiers

PMID: 14647447
DOI: 10.1038/sj.onc.1207199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing.PMID 14647447Read ↗

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The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cellsSemantic proximity Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.Semantic proximity Read ↗

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects.Semantic proximity Read ↗

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