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Article

Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2008

Nitani Naoki, Yadani Chie, Yabuuchi Hayato, Masukata Hisao, Nakagawa Takuro

Abstract excerpt

The minichromosome maintenance (MCM) helicase, composed of subunits Mcm2-7, is essential for the initiation and elongation phases of DNA replication. Even when DNA synthesis is blocked, MCM continues DNA unwinding to some extent for activation of the replication checkpoint and then stops. However, the mechanism of regulation of MCM-helicase activity remains unknown. Here, we show that truncation of the Mcm4...

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Identifiers

PMID: 18753627
DOI: 10.1073/pnas.0805307105
PMCID: PMC2529087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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