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Article

Regulation of DNA replication machinery by Mrc1 in fission yeast.

Genetics - 1 Sept 2006

Nitani Naoki, Nakamura Ken-ichi, Nakagawa Chie, Masukata Hisao, Nakagawa Takuro

Abstract excerpt

Faithful replication of chromosomes is crucial to genome integrity. In yeast, the ORC binds replication origins throughout the cell cycle. However, Cdc45 binds these before S-phase, and, during replication, it moves along the DNA with MCM helicase. When replication progression is inhibited, checkpoint regulation is believed to stabilize the replication fork; the detailed mechanism, however, remains unclear. To...

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Identifiers

PMID: 16849602
DOI: 10.1534/genetics.106.060053
PMCID: PMC1569812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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