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Article

Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks.

Nature structural & molecular biology - 1 May 2020

Devbhandari Sujan, Remus Dirk

Abstract excerpt

The coordination of DNA unwinding and synthesis at replication forks promotes efficient and faithful replication of chromosomal DNA. Disruption of the balance between helicase and polymerase activities during replication stress leads to fork progression defects and activation of the Rad53 checkpoint kinase, which is essential for the functional maintenance of stalled replication forks. The mechanism of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32341532
DOI: 10.1038/s41594-020-0407-7
PMCID: PMC7225081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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