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Article

Inhibition of CDK9 attenuates atherosclerosis by inhibiting inflammation and phenotypic switching of vascular smooth muscle cells.

Aging - 8 Jun 2021

Huang Shushi, Luo Wu, Wu Gaojun, Shen Qirui, Zhuang Zaishou, Yang Daona, Qian Jinfu, Hu Xiang, Cai Yan, Chattipakorn Nipon, Huang Weijian, Liang Guang

Abstract excerpt

BACKGROUND: Recent studies have demonstrated a key role of vascular smooth muscle cell (VSMC) dysfunction in atherosclerosis. Cyclin-dependent kinases 9 (CDK9), a potential biomarker of atherosclerosis, was significantly increased in coronary artery disease patient serum and played an important role in inflammatory diseases. This study was to explore the pharmacological role of CDK9 inhibition in attenuating...

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Identifiers

PMID: 34102609
DOI: 10.18632/aging.202998
PMCID: PMC8221363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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